WebTOPBP1 is believed to allosterically activate ATR via its ATR activation domain (AAD), located between BRCT6 and BRCT7 ( 10, 11 ). Recently, Ewing tumor-associated antigen 1 (ETAA1), containing a motif with sequence similarity to AAD, was identified as a second ATR-activator protein ( 15 – 17 ). Web16. mar 2009 · (B) TopBP1 is upregulated through deregulation of the pRb pathway or other mechanisms. Overexpression of TopBP1 in some cancer cells then may inhibit both p53 …
The deubiquitylating enzyme USP15 regulates homologous ... - Nature
Web28. apr 2012 · Aberrant expression of TopBP1 may lead to genomic instability and can have pathological consequences. In this study we aimed to investigate expression of TopBP1 … Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 demethylation is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from … globe life insurance of ny claims address
Functions of TopBP1 in preserving genome integrity during mitosis
Web1. máj 2024 · TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Web12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6). Moreover, increased levels of TopBP1 or Claspin endowed cells a higher resistance to … WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer. globe life insurance omaha ne