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Topbp1 cancer

WebTOPBP1 is believed to allosterically activate ATR via its ATR activation domain (AAD), located between BRCT6 and BRCT7 ( 10, 11 ). Recently, Ewing tumor-associated antigen 1 (ETAA1), containing a motif with sequence similarity to AAD, was identified as a second ATR-activator protein ( 15 – 17 ). Web16. mar 2009 · (B) TopBP1 is upregulated through deregulation of the pRb pathway or other mechanisms. Overexpression of TopBP1 in some cancer cells then may inhibit both p53 …

The deubiquitylating enzyme USP15 regulates homologous ... - Nature

Web28. apr 2012 · Aberrant expression of TopBP1 may lead to genomic instability and can have pathological consequences. In this study we aimed to investigate expression of TopBP1 … Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 demethylation is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from … globe life insurance of ny claims address https://raum-east.com

Functions of TopBP1 in preserving genome integrity during mitosis

Web1. máj 2024 · TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Web12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6). Moreover, increased levels of TopBP1 or Claspin endowed cells a higher resistance to … WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer. globe life insurance omaha ne

USP13 regulates the replication stress response by deubiquitinating TopBP1

Category:TOPBP1 Gene - Somatic Mutations in Cancer

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Topbp1 cancer

The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in …

Web27. apr 2024 · Taken together, our study reveals the functional defects of cancer-associated TOPBP1 mutations in DDR and may provide new therapy targets for cancer treatment. TOPBP1 (Topoisomerase IIβ-binding protein 1) mediates protein–protein interaction and … Web25. jan 2016 · TOPBP1 is a large, nine BRCT domain–containing protein with essential roles in cellular processes, including DNA repair, replication, and transcription ( Sokka et al., 2010 ). TOPBP1 enhances ATR kinase activity ( Kumagai et al., 2006) through interaction with ATR partner protein ATRIP ( Mordes et al., 2008 ).

Topbp1 cancer

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WebTopBP1 also acts as a transcriptional regulator, and we investigated how this activity influenced the HPV life cycle. We determined that TopBP1 levels are increased in cervical … Web17. nov 2014 · In Akt-hyperactive cancer, TopBP1 forms oligomers and represses E2F1-dependent apoptosis. Here we perform a molecular docking screening and identify a lead …

WebObjective: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many … Web15. mar 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy 29 June 2024 Yan Zhao, Xinping Huang, …

Web1. feb 2024 · However, the regulation of TopBP1 in DNA-damage responses remains unclear. In this study, we identify the deubiquitinating enzyme (DUB) USP13 as an important regulator of TopBP1. Mechanistically ... Web28. apr 2012 · Introduction. TopBP1 protein (topoisomerase IIβ binding protein 1) was identified as an interacting partner for topoisomerase IIβ [1, 2].TopBP1 possesses eight …

Web广西壮族自治区人民医院. 被引频次. 655. 成果数. 162. h指数. 14. g指数. 19. globe life insurance online bill paymenthttp://www.cancerindex.org/geneweb/TOPBP1.htm globe life insurance of new york addressWebData from the current study showed that topoisomerase IIβ binding protein 1 (TOPBP1), an interacting partner of topoisomerase IIβ, is highly expressed in oxaliplatin-resistant GC … boght hills elementaryWeb28. apr 2012 · TopBP1 possesses eight BRCA1 (breast cancer gene 1) carboxyl-terminal (BRCT) domains which were for the first time described for BRCA1 protein and are commonly found in proteins involved in regulation of the cell cycle checkpoint and the response of the cell to DNA damage [ 1, 3 – 5 ]. boght hills fire departmentWeb10. jan 2024 · Our studies show that TopBP1 expression is increased in cervical intraepithelial neoplasia and cervical squamous cell carcinoma as well as in HPV-positive cell lines in culture. Knockdown of... globe life insurance ohioWeb15. jan 2024 · To investigate the physiological role of TopBP1, we have generated germ cell-specific TopBP1-depleted mouse model. TopBP1-deleted mice were infertile, showed a loss of germ cells and had meiotic defects. ... (2013M3A6A4045755) of the National Research Foundation, South Korea, and the National Cancer Center Grant (NCC-1710190, 1810042) … boght hills elementary nyWebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. boght hills property services