Solubility of theophylline in water

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WebSolubility. Soluble in water (1.0 g/120 ml), ethanol (1.0 g/80 ml), chloroform (1.0 g/110 ml), hot water, ... and potassium salts and a large number of less basic salts and/or … WebDec 7, 2024 · Theophylline salts — Several so-called "salts” of theophylline had been developed as attempts to increase water solubility (8 mg/mL at 25ºC) and improve absorption. While salts of theophylline may be formed with a base at high pH, theophylline is only slightly ionized at physiological pH (pK a = 8.8).

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WebThe solubility of theophylline – oxalic acid co-crystal and theophylline – glutaric acid co-crystal was determined in 4:1 chlroform – methanol and in pure chloroform respectively. At equilibrium with the solid theophylline – oxalic acid co-crystal, the theophylline concentration is only 60 % of the corresponding value for the WebAminophylline is soluble in water and insoluble in alcohol. Theophylline occurs as bitter-tasting, odorless, white, crystalline powder with a melting point between 270-274°C. It is sparingly soluble in alcohol and only slightly soluble in water at a pH of 7, but solubility increases with increasing pH. csr property services

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WebJan 2, 2024 · Chemsrc provides Theophylline(CAS#:58-55-9) MSDS, density, melting point, boiling point, structure, formula, ... Solubility in water: slightly soluble Specific Gravity/Density: Molecular Formula: C7H8N4O2 Molecular Weight: 180.17 Section 10 - STABILITY AND REACTIVITY WebCommon-Ion Effect. The common-ion effect is a term that describes the decrease in solubility of an ionic compound when a salt that contains an ion that already exists in the chemical equilibrium is added to the mixture. This effect best be explained by Le Chatelier's principle.Imagine if the slightly soluble ionic compound calcium sulfate, CaSO 4, is added … WebJul 8, 2024 · Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured … csr projects ideas in sri lanka

Solubility and Factors Affecting Solubility - Chemistry LibreTexts

Theophylline anhydrous, = 99 , powder 58-55-9

WebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ... WebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ... csr property managementWebJan 1, 2015 · Theophylline is dimethylxanthine which is closely related chemically to caffeine (Fig. 1 ). Like caffeine, theophylline is sparingly soluble in water (7 g/l). The logP value of theophylline is –0.02 giving the unionized form sufficient lipid solubility to diffuse passively through cell membranes. Theophylline is a weak acid (pKa 8.8). ear ache after root canal

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Solubility of theophylline in water

Theophylline - an overview ScienceDirect Topics

WebThe observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simultaneous Chemical Reaction and … Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in …

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WebMar 1, 1983 · The solubilities of theophylline and theophylline hydrate as a function of temperature are determined in the temperature range 288–365K. The solubility as a … WebAug 1, 2024 · The equilibrium solubility of caffeine and theophylline were determined in {methanol + water} binary mixtures at 298.15 K by means of the shaken flask method and …

WebApr 14, 2024 · Purpose Nitrofurantoin is an effective antibacterial drug for the treatment of lower urinary tract infection. However, the anhydrate form can easily transform to the less soluble hydrate form (monohydrate) during dissolution, resulting in a reduction of dissolution rate and oral bioavailability. Therefore, inhibition of phase transformation is … WebAug 3, 2010 · The solubility of theophylline in water was modeled including hydrate formation (1:1) as well as polymorphic transitions of theophylline between the anhydrate …

WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, … WebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in …

WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was …

WebAug 24, 2024 · Solubility is a very important property of drugs involved in purification processes and the different pharmaceutical dosage form design stages. Otherwise, … csr property dataWebIncreasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica Zhouhua Wang,1,2 Bao Chen,1 Guilan Quan,1 Feng Li,1 Qiaoli Wu,1 Linghui Dian,1 Yixuan Dong,1 Ge Li,2 Chuanbin Wu1,21School of Pharmaceutical Sciences, 2Research and Development Center of … earache after putting wax remover in earWebTheophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates ... colorless solution. It is soluble in 0.1 M HCl, 0.1 M … csr provisions in companies act 2013WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was … csrp storeWebIt is also moderately soluble in ethanol. Furthermore, it is soluble in alcohol (12.5 mg/ml), and chloroform (9.1 mg/ml), alkali hydroxides, ammonia, dilute hydrochloric or nitric acid, … csrp spawn codesWebTheobromine solubility was studied in dioxane-water mixtures, a solvent system that was investigated earlier for the solubility of theophylline and caffeine. Solubilities were calculated in these polar systems by a regression method, based on an extension of the Hildebrand-Scatchard equation of regular solution theory. csrp st andrewsWebAug 1, 1994 · The results were treated on the basis of the extended Hildebrand solubility approach considering interaction terms. An equation has been obtained for predicting the … csrp staff menu