Lc3-interacting region lir

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August undefined, 2024

Web8 mei 2024 · This collective data show that M is a binding partner of LC3. Usually, binding partners of LC3 family members typically contain an LC3-interacting region (LIR). 2 LIRs form intermolecular β... Web10 jun. 2024 · LIR-mediated interaction with ATG8 proteins. The complex between LC3B and p62 [PDB entry: 2ZJD ( Ichimura et al., 2008 )] is reported as an example. LC3B mediates protein-protein interactions and recruits the autophagy receptors through the binding of a short linear motif, called LIR.

iLIR database: A web resource for LIR motif-containing …

Web23 nov. 2024 · We found that Trim5α binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a β … Web3 okt. 2024 · Atg8-family proteins play a central role in the autophagy process due to their ability to interact with components of the autophagy machinery as well as selective … churchill way macclesfield

pCMV-mCherry-p62(pCMV-mCherry-p62质粒)(D2818-1μg)

Web4 mei 2024 · Atg8 proteins are attached to membrane in a conjugation reaction and the cargo receptors bind them via short peptide motifs called Atg8-interacting motifs/LC3 … Web1 aug. 2013 · A main driving force has been the discovery of specific autophagy receptors that sequester cargo into forming autophagosomes (phagophores). At the heart of this selectivity lies the LC3-interacting region (LIR) motif, which ensures the targeting … Read Volume 126 Issue 15 of Journal of Cell Science. We are excited to … Web11 mei 2024 · Although the mechanism of autophagy inhibition through phosphorylation of LC3 proteins is still unclear, the possibility that phosphorylation of these sites interferes with the interaction of LC3 proteins with LIR-containing proteins is highly attractive and therefore may have serious consequences in the recruitment of AIM/LIR-dependent sensors. churchill way west post office

Development of GABARAP family protein-sensitive LIR-based …

Structure and Dynamics in the ATG8 Family From Experimental to ...

Web30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 displays cytoprotective and adaptogenic properties to modulate cellular homeostasis and survivability against hypoxia-induced stress. Web2 dagen geleden · TBC1D15 localized to damaged lysosomes via its C-terminal LC3-interacting region (LIR) motif, and its N terminus served as a platform to assemble the ALR machinery. churchill wealth advisory groupWebThe LC3-interacting region (LIR) motif as a mechanistic basis for mitophagy. a LC3B structure (PDB 1UGM) [179], analyzed using Chimera [180]. Upper panel ribbon … churchill way police station sheffield

"Web5 jan. 2024 · To predict LC3-interacting region (LIR) motif among these DEGs, the iLIR database was selected to assess specific short linear sequences. To obtain potential upstream miRNA targets of these DEGs, the mRNA-miRNA interaction networks were predicted by miRWalk database. " - Lc3-interacting region lir

Lc3-interacting region lir

NEK9 regulates primary cilia formation by acting as a ... - Nature

Web1 aug. 2013 · LIR-containing proteins include cargo receptors, members of the basal autophagy apparatus, proteins associated with vesicles and of their transport, Rab … Web1 sep. 2014 · The LC3 interaction region and UBA domain of NBR1 are required for pexophagy. ( A ) Schematic representation of NBR1. NBR1 contains a phox and Bem1 (PB1) domain (amino acid alignment positions at residue 1–86), coiled-coil (CC) domain (289–330), LC3-interacting region (LIR) (541–637 and 746–755), juxta-UBA domain …

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Web19 mrt. 2024 · The most prominent interaction mode is between the LC3 interacting region (LIR), also called Atg8 interacting motif (AIM), binding to the LIR docking site (LDS) in Atg8 homologs. There are variants of these motifs like “half-LIRs” and helical LIRs. Web15 feb. 2024 · ATG8 proteins have a pocket on their surface called the LC3-interacting region (LIR)–docking site (LDS), ... These adapters may also be degraded. Finally, a third class of LIR motif–containing proteins bind LC3 but escape degradation because, for example, the LC3 they bind falls off the surface before fusion with the lysosome ...

Web26 aug. 2024 · All of these receptors have an LC3-interacting region (LIR) motif to facilitate targeting to the autophagosomal membrane. Of the various cargo targeted by autophagy, intracellular bacterial pathogens represent one type of substrate that autophagy targets for degradation [9], [10], [11], [12]. WebpCMV-mCherry-p62是碧云天研发的在哺乳动物细胞中表达红色mCherry标签的人源p62融合蛋白的质粒。该质粒含有CMV启动子，为卡那霉素抗性，转染后能够在靶细胞中高效表达带有红色荧光蛋白mCherry标签的p62融合蛋白，呈现明亮的红色荧光，可以用于细胞自噬(autophagy)的研究

WebThe four amino acid linear LC3 interaction region (LIR) is shown in bold in its broader amino acid context. (B) Surface representation of the LIR binding site of LC3B in complex with a pS177 OPTN peptide (cyan). Region 1 (orange) and region 2 (purple) are shown. Web13 mei 2024 · LC3-II is the lipidated, phosphatidylethanolamine (PE)-conjugated membrane-associated species of LC3, which undergoes cleavage and lipidation following autophagy induction. The authors found that LC3-II is associated with immunopurified EVs [ 14 ], and is located within the lumen of purified EVs as evidenced by a protease-protection assay.

Web31 mrt. 2024 · LC3 interacting regions (LIRs), being quintessential for orchestrating diverse stages of autophagy, are a prominent example of SLiMs and mediate …

Web3 jan. 2024 · The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR) motifs that bind to the LIR docking site (LDS) of … devonshire sherlock holmesWeb31 mei 2024 · Thus, the LIR–LC3 interaction is essential for the formation, transport, and maturation of autophagosomes. Genetic mutations in LIR motifs may significantly alter … churchill wealthWeb2 jun. 2024 · In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs-interacting protein and find that NEK9 and its LC3-interacting region (LIR) are required for primary cilia formation.... devonshire shopping centerWeb16 mrt. 2012 · TP53INP1-LC3 interaction occurs via a functional LC3-interacting region (LIR). Inactivating mutations of this sequence abolish TP53INP1-LC3 interaction, … devonshires foodWeb30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 … devonshire shipWeb22 okt. 2024 · Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Small Molecules Experimental Data & … churchill way sheffieldWeb8 apr. 2024 · Efficient localization of HyD-2xLIRs-GFP to mRFP-LC3/GABARAP-positive autophagosomes. a Schematic model depicting the development of new autophagosome sensors. LIR: LC3-interacting region, HyD: hydrophobic domain. b Confocal images showing the cellular localization of HyD-LIR(X)-GFP or HyD-2xLIR(X)-GFP together with … churchill wealth management