Irf7 molecular weight
WebRegulation of expression. Study of IRF7 regulation is important as its expression is lymphoid specific. Although it has been shown that pDCs express a very high level of the translational inhibitors 4E-BP1 and -2, which may account for the extremely high level of … WebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood …
Irf7 molecular weight
Did you know?
WebAug 27, 2024 · Total IRF7 in the supernatants from lung homogenates was detected by IB analysis. (B and C) HEK293T cells were transiently transfected with Flag-NMI plasmid or EV together with Myc-IRF7 plasmid for 24 hours and then treated for various times with 10 μM CHX. IB images of IRF7 from cell lysates and quantitative analysis were shown. WebAB_2563007 (BioLegend Cat. No. 656004) Antigen Details Structure 503 amino acids, predicted molecular weight of 54 kD, contains an IRF tryptophan pentad repeat …
WebApr 12, 2024 · The close topographical and molecular associations between EVTs and cells in the decidua are crucial for the establishment and maintenance of pregnancy and have only been studied at certain ... TFs, such as ETV3, IRF7, and IRF5, were ... The node size indicated the number of connections and the line width indicated the weight of a … WebMar 21, 2024 · IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Predisposition To Severe Viral …
WebIRF7, once induced, is present in the cytoplasm as an inactive protein that is also phosphorylated on specific C-terminal residues by TBK1 and/or possibly IKKε kinases ( … WebMay 1, 2008 · IRF7 is an IFN-inducible transcription factor necessary for IFN-stimulated gene (ISG) induction by IFNs ( 29, 31, 32 ). When activated by phosphorylation, IRF7 translocates from the cytoplasm to the nucleus to induce target gene expression by binding to promoter regulatory elements ( 33, 34 ).
WebPartial IRF7 recombinant protein (127-503 a.a.) Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) ... 503 amino acids, predicted molecular weight of 54 kD, contains an IRF tryptophan pentad repeat responsible for DNA binding Distribution Shuttles between the cytoplasm and nucleus; activated ...
WebNov 30, 2024 · The molecular basis underlying stress hematopoiesis remains to be fully understood. In this study, we reported that IRF7 represents an important regulator of stress hematopoiesis. Interferon regulatory factor 7 (IRF7) was dispensable for normal hematopoiesis, whereas its deficiency significantly enhanced hematopoietic stem and … chronic obstructive pulmonary diseases copdWebApr 2, 2024 · To elucidate the molecular mechanisms of chicken IRF7 in the context of AIV infection in depth, ... of MAPK signaling pathway was observed to correlate with susceptible phenotypes of mutants such as significant weight loss, a higher mortality and a higher viral load with infection . A validation of the chicken IRF7 KO susceptibility phenotype ... derek peth and saffron vadherWebNov 21, 2024 · Cluster analysis unveiled distinct IRF7 hi versus IRF7 lo molecular phenotypes, the former exhibiting robust upregulation of Th1/type I interferon responses and the latter an alternative signature marked by upregulation of cytokine and growth factor signalling and downregulation of interferon gamma. derek pheby obituaryWebJan 16, 2024 · Production of HEK293FT IRF7 –/– Cell Lines. Human IRF7 gene is located in the locus 11p15.5 and encodes four isoforms that differ in the structure of the first three exons and alternative exclusion of 7th of 11 exons (A, B, C, and D) [].Initially, according to standard transcriptome analysis, it was found that the IRF7 gene mRNA isoforms a … chronic obstructive pulmonary disease webmdWebIRF1, IRF5, IRF7, IRF8 and IRF9 themselves are ISGs, which amplify initial IFN response in various cell types. Some of these proteins, IRF1, IRF3, IRF5, and IRF7 undergo a signal … derek peterson attorney indianaWebAnti-IRF7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. CoA References Brochures Technical Information Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Irf7 UniProt Number: P70434 ABF130 100 µL chronic obstructive pulmonary icd 10WebNov 26, 2024 · As expected, extracellular high molecular weight poly(I:C) did not induce Mda5 expression ... Irf7, or Irf9 (online suppl. Fig. 3a–c). IFN-α, LPS, and poly (I:C) induced Mda5 expression in macrophages. However, IRF1 inhibition led to a marked reduction in the expression of ... derek peth wife