WebThree-dimensional organization of the genome is important for transcriptional regulation 1-7.In mammals, CTCF and the cohesin complex create submegabase structures with … WebMay 3, 2024 · In order to image CTCF and cohesin without altering their endogenous expression levels, we used CRISPR/Cas9-mediated genome editing to homozygously tag Ctcf and Rad21 with HaloTag in mouse …
CTCF as a regulator of alternative splicing: new tricks for …
http://www.gpedia.com/zh/gpedia/%E4%BF%A1%E5%8F%B7%E8%BD%AC%E5%AF%BC%E5%8F%8A%E8%BD%AC%E5%BD%95%E6%BF%80%E6%B4%BB%E8%9B%8B%E7%99%BD WebDec 13, 2024 · Our results are consistent with cohesin-mediated loop extrusion in cells, and with CTCF both stopping and stabilizing cohesin. Surprisingly, the Fbn2 loop is both rare and dynamic, with a looped ... crash recording system
CTCF: insights into insulator function during development
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and … See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with cohesin, which extrudes chromatin loops by actively translocating one or two DNA strands through its ring-shaped structure, … See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more WebAug 27, 2024 · a Strategy for harvesting mitotic and post-mitotic populations with or without CTCF.b KR balanced Hi-C contact matrices showing global compartment reformation of chr1 in untreated and auxin ... WebFeb 20, 2024 · The postdoctoral researchers Dr. Stanimir Dulev and Dr. Yang Li confirmed interaction and co-localisation of SA and CTCF in the absence of cohesin using siRNA … diy wine lattice