Csf2ra
WebGenetic Factors. A series of reports have now established hereditary PAP as a newly described genetic disease caused by genetic mutations in CSF2RA or CSF2RB, which encode GM-CSF receptor α or β chains, respectively ( Fig. 70-3 ). 23-25,52,53 In some cases, the genes have been cloned, the defects reproduced in vitro, the signaling ... WebApr 8, 2024 · Harnessing the potential of this approach for gene therapy, we restored a disrupted Csf2ra gene in fetal liver monocytes and demonstrated their capacity to develop into alveolar macrophages in vivo. Altogether, we provide a platform for generation of immature alveolar macrophage-like precursors amenable for genetic manipulation, which …
Csf2ra
Did you know?
WebNov 26, 2014 · Juvenile pulmonary alveolar proteinosis (PAP) due to CSF2RA mutations is a rare disorder with only a few cases described worldwide. We identified nine children … WebBy using this site, you agree to our Terms and Conditions Got it!
WebApr 8, 2024 · As expected, Csf2ra-deficient fetal liver monocytes transduced with control RV gfp could not expand in culture (Figure 7, B and C). Notably, overexpression of Csf2ra in WT fetal liver monocytes also provided a slight growth advantage over nontransduced WT fetal liver monocytes in vitro (Figure 7, B and C). WebCSF2RA, colony stimulating factor 2 receptor subunit alpha Vertebrate Orthologs 2 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog CSF2RA, colony stimulating factor 2 receptor subunit alpha. Synonyms alphaGMR, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GMCSFR, GM-CSF-R …
http://www.informatics.jax.org/marker/MGI:1339754 WebAntibodies that detect CSF2RA (CD116) can be used in several scientific applications, including Western Blot, Flow Cytometry, Immunocytochemistry, Immunohistochemistry and ELISA. These antibodies target CSF2RA (CD116) in Human, Mouse and Rat samples. Our CSF2RA (CD116) monoclonal, polyclonal and recombinant monoclonal antibodies are …
WebMar 29, 2024 · CSF2RA colony stimulating factor 2 receptor subunit alpha Gene ID: 1438, updated on 29-Mar-2024 Gene type: protein coding Also known as: GMR; CD116; …
WebMar 9, 2024 · Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes (CSF2RA/CSF2RB, respectively) characterized by impaired GM-CSF-dependent surfactant clearance by alveolar macrophages (AMs) resulting in alveolar surfactant accumulation and … theroigneWebTo facilitate the translation of PMT therapy to human hPAP patients, a self-inactivating (SIN) lentiviral vector was generated expressing a codon-optimized human CSF2RA-cDNA driven from an EF1α short promoter (Lv.EFS.CSF2RA coop ), and a series of nonclinical efficacy and safety studies were performed in cultured macrophage cell lines and ... track of ida hurricaneWebDec 3, 2015 · CSF2RA expression also reduced the stemness of RUNX1-ETO bone marrow cells and inhibited their colony forming ability. To identify which region of the receptor … theroigne deWebColony stimulating factor 2 receptor alpha, low-affinity (granulocyte-macrophage). CD116 molecule. Back to the top. Specifications Human CSF2RA isoform_1 (pUNO1 … theroi horse historyWebThe gene view histogram is a graphical view of mutations across CSF2RA. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. theroiguy flannelWebDescription: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 11, non-coding RNA. RefSeq Summary (NR_027760): the roi is always positive. true falseWebThe gene view histogram is a graphical view of mutations across CSF2RA. These mutations are displayed at the amino acid level across the full length of the gene by default. … the roi is dated