WebA thiazole core has also been utilised by Solvay Pharmaceuticals [309] in the search for a novel bioisosterie replacement of the rimonabant (382) pyrazole core. The affinity of … Web1 Oct 2004 · Bioisosterie bedeutet gleiche räumliche Ausdehnung bei vergleichbarer Wirkung in biologischen Systemen. Dies bezieht sich auf pharmakologisch wirksame …

Bioisostere - Wikipedia

WebEn chimie pharmaceutique, un bioisostère est un groupe fonctionnel ou un composé chimique possédant des propriétés physiques, chimiques ou biochimiques … WebContextual translation of "bioisosterism" into German. Human translations with examples: bioisosterie. crock pot carry case

Bioisostère - C2SU

WebBioisosterie - pracovní hypotéza využívaná v metodě strukturních variací. Předpoklad: u strukturně podobných fragmentů s podobným rozložením hustoty elektronů lze očekávat … In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties in the same chemical compound. In drug design, the purpose of exchanging one bioisostere for another is to enhance … See more Classical bioisosteres Classical bioisosterism was originally formulated by James Moir and refined by Irving Langmuir as a response to the observation that different atoms with the same See more • Grimm's hydride displacement law, an early hypothesis to describe bioisosterism See more Bioisosteres of some patented compounds can be discovered automatically and used to circumvent Markush structure patent claims. It has been proposed that key force field features, … See more http://dictionary.sensagent.com/Isosterie/de-de/ buffet cable